UNMC part of $450 million COVID research study | Writing

UNMC is part of a four-year, nearly $450 million grant from the National Institutes of Health to study up to 20,000 adults and children to better understand the full extent of post-COVID symptoms in an effort to improve treatment and health outcomes.

Some of the questions to be asked by the NIH’s National Heart, Lung and Blood Institute’s RECOVER (Researching COVID to Enhance Recovery) research study include how many Americans have long-term effects from COVID, what their symptoms are, and how effects occur in the body.

“There’s not a good idea of ​​the prevalence or long-term side effects of long post-COVID syndrome. The intention is to figure that out. There’s a lot of disagreement,” said David Warren, PhD, assistant professor at UNMC. Department of Neurological Sciences and co-principal investigator of the research study. “We are thrilled to be able to contribute to a national effort. UNMC’s participation ensures that Nebraskans will be represented.

“It’s important that we understand what post-COVID looks like. It will help us understand the future of American health care, since most Americans have had it.”

According to the Centers for Disease Control and Prevention, up to 60% of people nationwide have been infected with COVID.

The UNMC team hopes to complete the registration of 85 participants by the fall. UNMC’s participation in the adult arm of the RECOVER study is part of a consortium led by West Virginia University.

Dr. Warren and co-lead researcher Andrew Vasey, MD, said those who may be eligible for the research study are adults 19 and older who have had COVID, as well as those who don’t think they have. had the COVID. The national research study will enroll approximately 17,700 adults, including approximately 15,000 people who have had COVID and approximately 2,700 people who do not.

Russell McCulloh, MD, principal investigator for the pediatric portion of the study, said children can also participate, from infants to 18, as well as those up to 25 who are still seeing pediatric providers. UNMC is participating in the pediatric arm of the RECOVER study as one of 14 Arkansas Children’s Research Institute hub consortium sites.

“We don’t know the long-term effects of COVID-19 on children’s health and development,” said Dr. McCulloh, associate professor of pediatrics at UNMC and division chief of pediatric hospital medicine at Children’s Hospital. & Medical Center. “We know that many children suffer from persistent symptoms of COVID-19 that can last for weeks or months, in addition to those who have suffered from severe acute illness due to multisystem inflammatory syndrome.”

Participants can make two to four visits per year. Involvement can include anything from being asked about their health, symptoms, physical activity and sleep between visits, to a medical checkup. In some cases, they may be eligible to receive medical tests.

There will be no treatment for post-COVID syndrome under RECOVER, but the research team may follow up with participants’ physicians about test results or possibilities for further post-COVID research. COVID.

For more information on adult eligibility, email the RECOVER Study through the UNMC. For the pediatric study, email the pediatric contact through the UNMC.

For more information, visit the study’s online site.

Clinical Trial Protocol 0766-21-CB

Paul N. Strickland